Background：This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.
仕様
Synonyms：hN CoR,hNCoR,KIAA1047,N CoR,N Cor/SMRT corepressor Rip13,N CoR1,N-CoR,N-CoR1,NCOR 1,NCoR,Ncor1,NCOR1,Nuclear receptor co repressor 1,Nuclear receptor corepressor 1,Retinoid X receptor interacting protein 13,RIP13,Rxrip13,thyroid hormone and retinoic acid receptor associated corepressor 1,TRAC 1,TRAC1
Host：Rabbit
Reactivity：Human
Applications：WB,IF
Concentration：1mg/ml
Immunogen：Recombinant protein of human NCOR1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000 IF1：50 - 1：100
Gene_ID（human）：9611
Swissprot：O75376
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling, Metabolism, Signal transduction
