Background：Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones （H2A, H2B, H3, and H4）. The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable X chromosome inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms.
仕様
Synonyms：Core histone macro h2a.1,Core histone macro-H2A.1,H2A histone family member Y ,H2A.y,H2A/y,H2AF12M,H2AFJ,H2afy,H2AY,Histone H2A.Y,Histone macroH2A1,Histone macroH2A1.1,Histone macroH2A1.2,Macroh2a1,MACROH2A1.1,MacroH2A1.2,Medulloblastoma antigen MU MB 50.205 ,Medulloblastoma antigen MU-MB-50.205,mH2a,mH2A1
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC,IF
Concentration：1mg/ml
Immunogen：Recombinant protein of human H2AFY
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
