Background：In acute myeloid leukemia, especially in the M2 subtype, the t（8;21）（q22;q22） translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 （AML1） gene fused to the 3'-region of the CBFA2T1 （MTG8） gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.
仕様
Synonyms：AML1 MTG8,cbfa2t2,Core binding factor runt domain alpha subunit 2 translocated to 2,core-binding factor, runt domain, alpha subunit 2,DKFZp313F2116,EHT,ETO homolog on chromosome 20,ETO homologous on chromosome 20,MTG 8 like protein,MTG 8 related protein 1,MTG8 like protein,MTG8 related protein 1,MTG8-like protein,MTG8-related protein 1,MTG8R,MTGR 1,Myeloid translocation gene related protein 1,Myeloid translocation related protein 1,Myeloid translocation-related protein 1,p85,Protein CBFA2T2,ZMYND 3,ZMYND3
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IF
Concentration：1mg/ml
Immunogen：Recombinant protein of human CBFA2T2
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
