Background：A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome （BLS; MIM 209920）. At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B, C, and D all lead to a deficiency in RFX, a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX （Steimle et al., 1995）. RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants have been found but the full-length natures of only two have been determined.
仕様
Synonyms：DNA binding protein RFX 5,DNA binding protein RFX5,DNA-binding protein RFX5,Influences HLA class II expression,Regulatory factor X 5,Regulatory factor X subunit 5,Regulatory factor X, 5 （influences HLA class II expression）,RFX 5,RFX5,Rfx5 protein ,RFX5
Host：Rabbit
Reactivity：Human
Applications：IF
Concentration：1mg/ml
Immunogen：Recombinant protein of human RFX5
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：IF1：50 - 1：100
Gene_ID（human）：5993
Swissprot：P48382
Isotype：IgG
Research Areas：Epigenetics and Nuclear Signaling, Immunology
