Background：The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase （AMPK）. AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase （ACC） and beta-hydroxy beta-methylglutaryl-CoA reductase （HMGCR）, key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Multiple alternatively spliced transcript variants have been found for this gene.
仕様
Synonyms：5' AMP activated protein kinase beta 2 subunit,5' AMP activated protein kinase subunit beta 2,5''-AMP-activated protein kinase subunit beta-2,AAKB2,AMP activated protein kinase beta 2 non catalytic subunit,AMPK beta 2,AMPK beta 2 chain,AMPK subunit beta 2,AMPK subunit beta-2,MGC61468,PRKAB 2,Prkab2,Protein kinase AMP activated beta 2 non catalytic subunit
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：Recombinant protein of human PRKAB2
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000 IHC1：50 - 1：200
Gene_ID（human）：5565
Swissprot：O43741
Isotype：IgG
Research Areas：Cancer, Cardiovascular, Metabolism, Signal transduction
