Background：The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly（A） as the substrate, hence, efficiently degrades poly（A） tails of mRNAs. Exonucleolytic degradation of the poly（A） tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay （NMD） of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
仕様
Synonyms：DAN,Deadenylating nuclease,Deadenylation nuclease,PARN,PARN,Poly A specific ribonuclease,Poly（A） specific ribonuclease,Poly（A）-specific ribonuclease PARN,Polyadenylate specific ribonuclease,Polyadenylate-specific ribonuclease
Host：Rabbit
Reactivity：Human
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human PARN
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB 1：500 - 1：2000
Gene_ID（human）：5073
Swissprot：O95453
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
