Background：This gene encodes a member of the AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome family of proteins, which have been implicated in childhood lymphoblastic leukemia, Fragile X E site mental retardation, and ataxia. It is the prevalent mixed-lineage leukemia fusion gene associated with spontaneous acute lymphoblastic leukemia. Members of this family have three conserved domains： an N-terminal homology domain, an AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome domain, and a C-terminal homology domain. The protein functions as a regulator of RNA polymerase II-mediated transcription through elongation and chromatin remodeling functions. Through RNA interference screens, this gene has been shown to promote the expression of CD133, a plasma membrane glycoprotein required for leukemia cell survival. Alternative splicing results in multiple transcript variants.
仕様
Synonyms：AF 4,AF 4 protein,AF4,AF4-MLL,AF4/FMR2 family member 1,AFF 1,AFF1,AFF1,ALL1 fused gene from chromosome 4,ALL1-fused gene from chromosome 4 protein,FEL,MGC134969,MLL/AF4,MLLT2,myeloid/lymphoid or mixed lineage leukemia （trithorax homolog, Drosophila）; translocated to, 2,MYELOID/LYMPHOID OR MIXED LINEAGE LEUKEMIA TRANSLOCATED TO 2; MLLT2,PBM1,Pre B cell monocytic leukemia partner 1,Protein AF-4,Protein FEL,Proto-oncogene AF4
Host：Rabbit
Reactivity：Human
Applications：IF
Concentration：1mg/ml
Immunogen：Recombinant protein of human AFF1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：IF1：50 - 1：100
Gene_ID（human）：4299
Swissprot：P51825
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
