Background：This gene encodes a TBP- （TATA box-binding protein） associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription.
仕様
Synonyms：Down regulator of transcription 1,Down regulator of transcription 1 TBP binding,Down-regulator of transcription 1,down-regulator of transcription 1, TBP-binding （negative cofactor 2）,DR 1,Dr1,Dr1 protein,NC 2,NC2,NC2 beta,NC2-beta,NC2B,Negative co factor 2,Negative cofactor 2,Negative cofactor 2 beta,Negative cofactor 2-beta,Protein Dr1,TATA binding protein associated phosphoprotein,TATA box/binding protein associated phosphoprotein DR1,TATA-binding protein-associated phosphoprotein
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：Recombinant protein of human DR1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB 1：500 - 1：2000 IHC 1：50 - 1：200
Gene_ID（human）：1810
Swissprot：Q01658
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
