Background：This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.
仕様
Synonyms：AP 13,API3,Apoptosis Inhibitor 3,Baculoviral IAP repeat containing 4,Baculoviral IAP Repeat Containing Protein 4,Baculoviral IAP repeat-containing protein 4,BIRC 4,BIRC4,E3 ubiquitin-protein ligase XIAP,hIAP-3,hIAP3,HILP,IAP 3,IAP like protein,IAP-3,IAP-like protein,IAP3,ILP 1,ILP,ILP1,Inhibitor of apoptosis protein 3,Inhibitor of Apoptosis X Linked,Mammalian IAP Homologue A,MIHA,X linked IAP,X linked inhibitor of apoptosis,X linked inhibitor of apoptosis E3 ubiquitin protein ligase,X linked inhibitor of apoptosis protein,X-linked IAP,X-linked inhibitor of apoptosis protein,Xiap,XIAP,XLP2
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：Recombinant protein of human XIAP
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
