Background：This gene encodes a member of the RecQ subfamily and the DEAH （Asp-Glu-Ala-His） subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging.
仕様
Synonyms：DKFZp686C2056,DNA helicase,DNA helicase, RecQ like type 3,Exonuclease WRN,HGNC 12791,OTTHUMP00000225301,RecQ protein-like 2,RecQ-like type 3,RecQ3,RECQL2,RECQL3,Werner syndrome ATP-dependent helicase,Werner syndrome helicase,Werner syndrome protein,Werner syndrome, RecQ helicase like,WRN,WRN
Host：Rabbit
Reactivity：Human
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human WRN
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：200 - 1：1000
Gene_ID（human）：7486
Swissprot：Q14191
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
