Background：The Fanconi anemia complementation group （FANC） currently includes FANCA, FANCB, FANCC, FANCD1 （also called BRCA2）, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ （also called BRIP1）, FANCL, FANCM and FANCN （also called PALB2）. The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group L. Alternative splicing results in two transcript variants encoding different isoforms.
仕様
Synonyms：E3 ubiquitin-protein ligase FANCL,FAAP43,Fancl,FANCL,Fanconi anemia complementation group L,Fanconi anemia group L protein,Fanconi anemia-associated polypeptide of 43 kDa,FLJ10335,PHD finger protein 9,PHF9,POG,Ubiquitin ligase protein FANCL
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：Recombinant protein of human FANCL
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：200 - 1：2000 IHC1：20 - 1：200
Gene_ID（human）：55120
Swissprot：Q9NW38
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
