Background：This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA.
仕様
Synonyms：Activator of RNA decay,ARD 1,ARD-1,ARD1,Homolog of E.coli RNase E,NIPP 1,NIPP-1,NIPP1,Nuclear inhibitor of protein phosphatase 1,nuclear inhibitor of protein phosphatase-1 alpha,Nuclear subunit of PP1,PP1R8,PPP1R8,PRO2047 ,Protein phosphatase 1 regulatory inhibitor subunit 8,Protein phosphatase 1 regulatory subunit 8,RNase E,RNase E, E. coli, homolog of
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：Recombinant protein of human PPP1R8
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB 1：500 - 1：2000 IHC 1：50 - 1：200
Gene_ID（human）：5511
Swissprot：Q12972
Isotype：IgG
Research Areas：Epigenetics and Nuclear Signaling, Signal transduction
