Background：This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase （MAPK） signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 （also known as SMURF1） via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.
仕様
Synonyms：C7orf22,Ccm2,CCM2 gene,CCM2,Cerebral cavernous malformation 2,Cerebral cavernous malformations 2 protein,Chromosome 7 open reading frame 22,Malcavernin,MGC4067,MGC4607,MGC74868,OSM,Osmosensing scaffold for MEKK3,OTTHUMP00000159554,OTTHUMP00000214270,OTTHUMP00000214271,OTTHUMP00000214273,PP10187
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：Recombinant protein of human CCM2
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
