Background：The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known.
仕様
Synonyms：Chromatin-specific transcription elongation factor 80 kDa subunit,Cisplatin DNA SSRP,Facilitates chromatin remodeling 80 kDa subunit,Facilitates chromatin transcription complex 80 kDa subunit,Facilitates chromatin transcription complex subunit SSRP1,FACT 80 kDa subunit,FACT complex subunit SSRP1,FACT80,FACTp80,hSSRP1,Recombination signal sequence recognition protein 1,Recombination signal sequence recognition protein,SSRP 1,SSRP1,SSRP1,Structure specific recognition protein 1,Structure-specific recognition protein 1,T160
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：Recombinant protein of human SSRP1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB 1：500 - 1：2000 IHC 1：50 - 1：200
Gene_ID（human）：100413716
Swissprot：Q08945
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
