Background：The protein encoded by this gene is a member of the protein tyrosine phosphatase （PTP） family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus （IDDM） patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.
仕様
Synonyms：CA 512,FLJ16131,IA 2,IA 2/PTP,IA2,IA2/PTP,ICA 3,ICA 512,ICA3,ICA512,Islet cell antigen 2,Islet cell antigen 512,Islet cell autoantigen 3,Protein tyrosine phosphatase like N,Protein tyrosine phosphatase like N precursor,Protein tyrosine phosphatase receptor type N,PTP IA 2,PTP IA-2,PTP IA2,PTPIA 2,PTPN,Ptprn,PTPRN protein,PTPRN,R PTP N,R-PTP-N,Receptor type tyrosine protein phosphatase like N,Receptor-type tyrosine-protein phosphatase-like N,RPTPN
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human PTPRN
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000
Gene_ID（human）：5798
Swissprot：Q16849
Isotype：IgG
Research Areas：Cancer, Metabolism, Neuroscience, Signal transduction
