Background：This gene encodes a member of the pterin-4-alpha-carbinolamine dehydratase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein functions as both a dehydratase involved in tetrahydrobiopterin biosynthesis, and as a cofactor for HNF1A-dependent transcription. A deficiency of this enzyme leads to hyperphenylalaninemia. Alternative splicing results in multiple transcript variants.
仕様
Synonyms：4 alpha hydroxy tetrahydropterin dehydratase,4-alpha-hydroxy-tetrahydropterin dehydratase,6 pyruvoyl tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha （TCF1）,6 pyruvoyl tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha,DCoH,Dimerization cofactor of hepatic nuclear factor 1 alpha,Dimerization cofactor of hepatocyte nuclear factor 1 alpha,Dimerization cofactor of hepatocyte nuclear factor 1-alpha,Dimerization cofactor of HNF1,Dimerizing cofactor for HNF1,PCBD 1,PCBD,PCBD1,PCD,Phenylalanine hydroxylase stimulating protein,Phenylalanine hydroxylase-stimulating protein,PHS,PHS,Pterin 4 alpha carbinolamine dehydratase,Pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha （TCF1）,Pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha,Pterin carbinolamine dehydratase,Pterin-4-alpha-carbinolamine dehydratase
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IF
Concentration：1mg/ml
Immunogen：Recombinant protein of human PCBD1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000 IF1：10 - 1：100
Gene_ID（human）：5092
Swissprot：P61457
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling, Metabolism, Signal transduction
