Background：This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants.
仕様
Synonyms：C4b binding protein beta chain,C4b-binding protein beta chain,C4BP,C4BPB,C4BPB,Complement component 4 binding protein beta,Complement component 4 binding protein beta chain,Complement component 4-binding protein beta,OTTHUMP00000034288,OTTHUMP00000034289,OTTHUMP00000034375,OTTHUMP0000003474,Proline rich protein,PRP
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC,IF
Concentration：1mg/ml
Immunogen：Recombinant protein of human C4BPB
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
