Background：The protein encoded by this gene inhibits acetylation of nucleosomes, especially histone H4, by histone acetylases （HAT）. This inhibition is most likely accomplished by masking histone lysines from being acetylated, and the consequence is to silence HAT-dependent transcription. The encoded protein is part of a complex localized to the endoplasmic reticulum but is found in the nucleus and inhibits apoptosis following attack by cytotoxic T lymphocytes. This protein can also enhance DNA replication of the adenovirus genome. Several transcript variants encoding different isoforms have been found for this gene.
仕様
Synonyms：2PP2A ,HLA DR associated protein II ,HLA-DR-associated protein II,I 2PP2A ,I-2PP2A,I2PP2A,IGAAD,Inhibitor of granzyme A activated DNase ,Inhibitor of granzyme A-activated DNase,Inhibitor of GzmA-activated DNase,inhibitor-2 of protein phosphatase-2A,IPP2A2,PHAPII,Phosphatase 2A inhibitor I2PP2A,protein phosphatase type 2A inhibitor,Protein SET,Set,SET nuclear oncogene,SET translocation ,SET translocation （myeloid leukemia-associated）,SET,TAF I ,TAF IBETA,TAF-I,TAFI,Template activating factor I ,Template-activating factor I,Template-Activating Factor-I, chromatin remodelling factor
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：Recombinant protein of human SET
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000 IHC1：50 - 1：200
Gene_ID（human）：6418
Swissprot：Q01105
Isotype：IgG
Research Areas：Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Immunology, Signal transduction
