Background：This gene encodes a member of the low density lipoprotein （LDL） receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- （regulated intramembrane proteolysis） processing but the precise locations of the cleavage sites have not been determined.
仕様
Synonyms：ADCAD2,C030016K15Rik,Cd,FLJ90062,FLJ90421,LDL receptor related protein 6,Low density lipoprotein receptor related protein 6,Low-density lipoprotein receptor-related protein 6,LRP-6,LRP6,LRP6,OTTHUMP00000238979,OTTHUMP00000238980,OTTHUMP00000238982,STHAG7
Host：Rabbit
Reactivity：Mouse,Rat
Applications：WB
Concentration：1mg/ml
Immunogen：A synthetic peptide of human LRP6
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Dilution：WB 1：500 - 1：1000
Gene_ID（human）：4040
Swissprot：O75581
Isotype：IgG
Research Areas：Cancer, Signal transduction, Stem cells
