Background：This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins （hnRNPs）. The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA （hnRNA）. These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif （RRM） domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.
仕様
Synonyms：57 kDa RNA binding protein PPTB 1,57 kDa RNA-binding protein PPTB-1,Heterogeneous nuclear ribonucleoprotein I,Heterogeneous Nuclear Ribonucleoprotein Polypeptide I,hnRNP I,HNRNP-I,HNRNPI,HNRPI,MGC10830,MGC8461,Polypyrimidine tract binding protein （heterogeneous nuclear ribonucleoprotein I）,Polypyrimidine Tract Binding Protein 1,Polypyrimidine tract binding protein,Polypyrimidine tract-binding protein 1,pPTB,PTB 1,PTB 2,PTB 3,PTB 4,PTB,PTB T,PTB1,PTB2,PTB3,PTB4,PTBP 1,PTBP1,PTBP1,PTBT,RNA Binding Protein
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：A synthetic peptide of human PTBP1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：1000 IHC1：100 - 1：200
Gene_ID（human）：5725
Swissprot：P26599
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
