Background：Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is a component of both U2- and U12-dependent spliceosomes, and found to be essential for the catalytic step II in pre-mRNA splicing process. It contains several WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp8 protein. This gene is a candidate gene for autosomal dominant retinitis pigmentosa.
仕様
Synonyms：220 kDa U5 snRNP specific protein,220 kDa U5 snRNP-specific protein,Apoptosis regulated protein 1,Apoptosis regulated protein 2,HPRP8,p220,Pre mRNA processing factor 8,Pre mRNA-processing factor 8, S. cerevisiae, homolog of,Pre-mRNA-processing-splicing factor 8,Precursor mRNA processing protein ,PRP8,PRP8 homolog,PRP8 pre mRNA processing factor 8 homolog ,PRP8,PRPC8,Prpf8,Retinitis pigmentosa 13 （autosomal dominant）,RP13,SNRNP220,Splicing factor Prp8,U5 snRNP specific protein ,U5 snRNP specific protein （220 kD）, ortholog of S. cerevisiae Prp8p
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：A synthetic peptide of human PRPF8
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB 1：500 - 1：1000 IHC 1：50 - 1：100
Gene_ID（human）：10594
Swissprot：Q6P2Q9
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling, Neuroscience
