Background：This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly（A） tails. The protein is required for progressive and efficient polymerization of poly（A） tails at the 3' ends of eukaryotic transcripts and controls the size of the poly（A） tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly（A） binding protein is localized in the cytoplasm. This gene contains a GCG trinucleotide repeat at the 5' end of the coding region, and expansion of this repeat from the normal 6 copies to 8-13 copies leads to autosomal dominant oculopharyngeal muscular dystrophy （OPMD） disease. Related pseudogenes have been identified on chromosomes 19 and X. Read-through transcription also exists between this gene and the neighboring upstream BCL2-like 2 （BCL2L2） gene.
仕様
Synonyms：Nuclear poly（A）-binding protein 1,OPMD,PAB2,PABII,PABP 2,pABP-2,PABP2,PABP2,PABPII,Pabpn1,poly（A） binding protein nuclear 1 ,Poly（A）-binding protein 2,Poly（A）-binding protein II,PolyA binding protein II,Polyadenylate-binding nuclear protein 1,Polyadenylate-binding protein 2
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB
Concentration：1mg/ml
Immunogen：A synthetic peptide of human PABPN1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB 1：500 - 1：1000
Gene_ID（human）：8106
Swissprot：Q86U42
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
