Background：This gene encodes a LIN-28 family RNA-binding protein that acts as a posttranscriptional regulator of genes involved in developmental timing and self-renewal in embryonic stem cells. The encoded protein functions through direct interaction with target mRNAs and by disrupting the maturation of certain miRNAs involved in embryonic development. This protein prevents the terminal processing of the LET7 family of microRNAs which are major regulators of cellular growth and differentiation. Aberrant expression of this gene is associated with cancer progression in multiple tissues.
仕様
Synonyms：AL024421,CSDD1,CSDD2,FLJ12457,Lin 28,Lin 28 homolog （C. elegans）,Lin 28 homolog A （C. elegans）,Lin 28 homolog A,Lin 28 homolog,Lin-28A,Lin28,Lin28,C. elegans,homolog of,A,LIN28A,LN28A,Protein lin-28 homolog A,Protein lin-28 homolog B,RNA binding protein lin 28,Tex17,ZCCHC1,Zinc finger CCHC domain containing 1,Zinc finger CCHC domain containing protein 1,Zinc finger CCHC domain-containing protein 1
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human LIN28A
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB 1：500 - 1：1000
Gene_ID（human）：79727
Swissprot：Q9H9Z2
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling, Developmental biology, Neuroscience, Stem cells
