Background：This gene encodes a member of the argonaute family of proteins, which associate with small RNAs and have important roles in RNA interference （RNAi） and RNA silencing. This protein binds to microRNAs （miRNAs） or small interfering RNAs （siRNAs） and represses translation of mRNAs that are complementary to them. It is also involved in transcriptional gene silencing （TGS） of promoter regions that are complementary to bound short antigene RNAs （agRNAs）, as well as in the degradation of miRNA-bound mRNA targets. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target, and that its mRNA could give rise to an additional C-terminally extended isoform by use of an alternative in-frame translation termination codon.
仕様
Synonyms：AGO1,AGO1,Argonaute 1,Argonaute 1 RISC catalytic component,Argonaute1,eIF 2C 1,eIF-2C 1,eIF2C 1,EIF2C,Eif2c1,Eukaryotic translation initiation factor 2C 1,GERP95,Golgi Endoplasmic Reticulum protein 95 kDa,hAgo1,Protein argonaute 1,Protein argonaute-1,Putative RNA binding protein Q99,Putative RNA-binding protein Q99,Q99
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human AGO1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB 1：500 - 1：1000
Gene_ID（human）：26523
Swissprot：Q9UL18
Isotype：IgG
Research Areas：Cancer, Cell Biology, Epigenetics and Nuclear Signaling
