Background：This gene encodes the second largest subunit of RNA polymerase II （Pol II）, a DNA-dependent RNA polymerase that catalyzes the transcription of DNA into precursors of mRNA, snRNA and microRNA. This subunit and the largest subunit form opposite sides of the center cleft of Pol II. Deletion of the flap loop region of this subunit results in a decrease in the rate of transcriptional elongation. Alternative splicing results in multiple transcript variants.
仕様
Synonyms：DNA directed RNA polymerase II 140 kDa polypeptide,DNA-directed RNA polymerase II subunit B,hRPB140,hsRPB2,POL2RB,Polymerase （RNA） II （DNA directed） polypeptide B （140kD） ,RNA polymerase II 140kD subunit,RNA polymerase II second largest subunit,RNA polymerase II subunit 2,RNA polymerase II subunit B2
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：Recombinant protein of human POLR2B
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000 IHC1：50 - 1：200
Gene_ID（human）：5431
Swissprot：P30876
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
