Background：The protein encoded by this gene is a transcription factor required for T-cell expression of the interleukin 2 gene. It also binds RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. The encoded 45 kDa protein （NF45, ILF2） forms a complex with the 90 kDa interleukin enhancer-binding factor 3 （NF90, ILF3）, and this complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm, to repair DNA breaks by nonhomologous end joining, and to negatively regulate the microRNA processing pathway. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. Alternative splicing results in multiple transcript variants. Related pseudogenes have been found on chromosomes 3 and 14.
仕様
Synonyms：HGNC：6037,ILF 2,ilf2,ILF2,Interleukin enhancer binding factor 2,Interleukin enhancer binding factor 2,45kDa,Interleukin enhancer-binding factor 2,MGC8391,NF 45,NF45,Nuclear factor of activated T cells 45 kDa,Nuclear factor of activated T-cells 45 kDa,PRO3063
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：Recombinant protein of human ILF2
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB 1：500 - 1：2000 IHC 1：50 - 1：200
Gene_ID（human）：3608
Swissprot：Q12905
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
