Background：Mitochondrial uncoupling proteins （UCP） are members of the family of mitochondrial anion carrier proteins （MACP）. UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat.
仕様
Synonyms：Uncoupling Protein 1,Uncoupling Protein 1 （Mitochondrial, Proton Carrier）,Solute Carrier Family 25 Member 7,Thermogenin,SLC25A7,UCP,Mitochondrial Brown Fat Uncoupling Protein 1,UCP 1.
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human UCP1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000
Gene_ID（human）：7350
Swissprot：P25874
Isotype：IgG
Research Areas：Cancer, Metabolism, Signal transduction
