Background：The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed.
仕様
Synonyms：1300013A07Rik,Eaf 4,Eaf4,FLJ20089,ING 2,ING 3,ING2,ING3,ING3,Inhibitor of growth family member 3,Inhibitor of growth protein 3,MEAF4,p47 ING 3,p47 ING3,p47 regulator protein,p47ING3,p47ING3 protein
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IF
Concentration：1mg/ml
Immunogen：Recombinant protein of human ING3
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000 IF1：50 - 1：200
Gene_ID（human）：54556
Swissprot：Q9NXR8
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
