Background：The CLCN family of voltage-dependent chloride channel genes comprises nine members （CLCN1-7, Ka and Kb） which demonstrate quite diverse functional characteristics while sharing significant sequence homology. The protein encoded by this gene regulates the electric excitability of the skeletal muscle membrane. Mutations in this gene cause two forms of inherited human muscle disorders： recessive generalized myotonia congenita （Becker） and dominant myotonia （Thomsen）. Alternative splicing results in multiple transcript variants.
仕様
Synonyms：Chloride channel protein 1,Chloride channel protein,Chloride channel protein skeletal muscle,CIC 1,CIC1,ClC-1,CLC1,Clcn1,CLCN1,MGC138361,MGC142055,skeletal muscle
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human CLCN1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000
Gene_ID（human）：1180
Swissprot：P35523
Isotype：IgG
Research Areas：Metabolism, Neuroscience, Signal transduction
