Background：This gene encodes the beta subunit of the mitochondrial trifunctional protein, which catalyzes the last three steps of mitochondrial beta-oxidation of long chain fatty acids. The mitochondrial membrane-bound heterocomplex is composed of four alpha and four beta subunits, with the beta subunit catalyzing the 3-ketoacyl-CoA thiolase activity. The encoded protein can also bind RNA and decreases the stability of some mRNAs. The genes of the alpha and beta subunits of the mitochondrial trifunctional protein are located adjacent to each other in the human genome in a head-to-head orientation. Mutations in this gene result in trifunctional protein deficiency. Alternatively spliced transcript variants encoding different isoforms have been described.
仕様
Synonyms：2 enoyl Coenzyme A （CoA） hydratase beta subunit,3 ketoacyl Coenzyme A （CoA） thiolase of mitochondrial trifunctional protein beta subunit,3 ketoacyl Coenzyme A thiolase,3 ketoacyl Coenzyme A thiolase of mitochondrial trifunctional protein beta subunit,3-ketoacyl-CoA thiolase,Acetyl CoA acyltransferase,Acetyl-CoA acyltransferase,Beta ketothiolase,Beta-ketothiolase,ECHB,ECHB,HADH,Hadhb,Hydroxyacyl CoA dehydrogenase/3 ketoacyl CoA thiolase/enoyl CoA hydratase （trifunctional protein）, beta subunit,Hydroxyacyl Coenzyme A （CoA） dehydrogenase beta subunit,Hydroxyacyl Coenzyme A dehydrogenase,Hydroxyacyl Coenzyme A dehydrogenase beta subunit,Hydroxyacyl Coenzyme A dehydrogenase/3 ketoacyl Coenzyme A thiolase/enoyl Coenzyme A hydratase （trifunctional protein） beta subunit,MGC87480,Mitochondrial trifunctional enzyme beta subunit,Mitochondrial trifunctional protein beta subunit,MSTP 029,MSTP029,MTPB,TP beta,TP-beta,TPbeta,Trifunctional enzyme subunit beta,Trifunctional enzyme subunit beta mitochondrial,Trifunctional protein
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IF
Concentration：1mg/ml
Immunogen：Recombinant protein of human HADHB
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000 IF1：10 - 1：100
Gene_ID（human）：3032
Swissprot：P55084
Isotype：IgG
Research Areas：Cancer, Metabolism, Signal transduction
