Background：The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor （TNF） ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13.
仕様
Synonyms：APO 3 ligand,APO 3L,APO3 ligand,APO3/DR3 ligand,APO3L,DR3LG,MGC129581,MGC20669,secreted form,TNF-related weak inducer of apoptosis,TNF12,TNFSF 12,Tnfsf12,TNFSF12 protein,Tumor necrosis factor （ligand） superfamily member 12,Tumor necrosis factor ligand superfamily member 12,Tumor necrosis factor superfamily member 12,TWEAK,UNQ181/PRO207
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：Recombinant protein of human TNFSF12
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
