Background：The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A （FKBP1A）, but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins （hsp90 and hsp70） and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors （AAV） resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene.
仕様
Synonyms：51 kDa FK506-binding protein,52 kDa FK506 binding protein,52 kDa FK506-binding protein,52 kDa FKBP,59 kDa immunophilin,FK506 binding protein 4,FK506-binding protein 4,FKBP 4,FKBP 52,FKBP 59,FKBP-4,FKBP-52,FKBP4,FKBP4,FKBP51,FKBP52 protein,FKBP59,HBI,Hsp 56,HSP binding immunophilin,HSP-binding immunophilin,Hsp56,Immunophilin FKBP52,N-terminally processed,p52,p59,p59 protein,Peptidyl prolyl cis trans isomerase,Peptidyl-prolyl cis-trans isomerase FKBP4,Peptidylprolyl cis trans isomerase,PPIase,PPIase FKBP4,Rotamase,T cell FK506 binding protein 59kD
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB,IHC,IF,IP
Concentration：1mg/ml
Immunogen：Recombinant protein of human FKBP4
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
