Background：The protein encoded by this gene is a member of the large DEAD-box protein family, that is defined by the presence of the conserved Asp-Glu-Ala-Asp （DEAD） motif, and has ATP-dependent RNA helicase activity. This protein has been reported to display a high level of RNA-independent ATPase activity, and unlike most DEAD-box helicases, the ATPase activity is thought to be stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. This gene has a paralog located in the nonrecombining region of the Y chromosome. Pseudogenes sharing similarity to both this gene and the DDX3Y paralog are found on chromosome 4 and the X chromosome. Alternative splicing results in multiple transcript variants.
仕様
Synonyms：ATP dependent RNA helicase DDX3X,ATP-dependent RNA helicase DDX3X,CAP Rf,DBX,DDX14,DDX3X,DDX3X,DEAD （Asp Glu Ala Asp） box polypeptide 3 X linked,DEAD （Asp-Glu-Ala-Asp） box helicase 3,X-linked,DEAD box,DEAD box protein 3,DEAD box protein 3 X-chromosomal,DEAD box X isoform,DEAD box,X isoform,DEAD/H （Asp Glu Ala Asp/His） box polypeptide 3,DEAD/H box 3,DEAD/H box 3,X-linked,Helicase like protein 2,Helicase-like protein 2,HLP2,X isoform,X-chromosomal
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB,IF
Concentration：1mg/ml
Immunogen：Recombinant protein of human DDX3X
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Dilution：WB1：500 - 1：2000 IF1：50 - 1：200
Gene_ID（human）：1654
Swissprot：O00571
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling, Developmental biology, Stem cells
