Background：This gene encodes a member of the cyclin-dependent protein kinase （CDK） family. CDK family members are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit, cyclin C, are components of the Mediator transcriptional regulatory complex, involved in both transcriptional activation and repression by phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II. This kinase regulates transcription by targeting the cyclin-dependent kinase 7 subunits of the general transcription initiation factor IIH, thus providing a link between the Mediator complex and the basal transcription machinery. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.
仕様
Synonyms：cdk8,CDK8 protein kinase,CDK8,Cell Division Kinase 8,Cell division protein kinase 8,Cyclin Dependent kinase 8,Cyclin-dependent kinase 8,K35,Mediator complex subunit cdk8,Mediator of RNA polymerase II transcription subunit cdk8,Protein kinase K35
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human CDK8
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000
Gene_ID（human）：1024
Swissprot：P49336
Isotype：IgG
Research Areas：Cell Biology, Epigenetics and Nuclear Signaling
