Background：Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform （p26） has been described.
仕様
Synonyms：2-hydroxy-dATP diphosphatase,7 8 dihydro 8 oxoguanine triphosphatase,7,8 oxo 7 8 dihydrodeoxyguanosine triphosphatase,8 oxo 7 8 dihydroguanosine triphosphatase,8 oxo dGTPase,8-dihydro-8-oxoguanine triphosphatase,8-oxo-dGTPase,8ODP,MTH 1,MTH1,MutT human homolog 1,Nucleoside diphosphate linked moiety X motif 1,Nucleoside diphosphate linked moiety X type motif 1,Nucleoside diphosphate-linked moiety X motif 1,Nudix （nucleoside diphosphate linked moiety X） type motif 1,Nudix hydrolase 1,Nudix motif 1,Nudix type motif 1,NUDT 1,Nudt1
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human NUDT1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB 1：500 - 1：2000
Gene_ID（human）：4521
Swissprot：P36639
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
