Background：Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha （TNF-alpha） and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppressor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C （CMT1C） and may be involved in the carcinogenesis of extramammary Paget's disease （EMPD）. Multiple alternatively spliced transcript variants have been found for this gene.
仕様
Synonyms：Lipopolysaccharide induced TNF alpha factor,CMT1C,FLJ38636,Lipopolysaccharide induced TNF alpha factor,Lipopolysaccharide induced TNF factor,Lipopolysaccharide induced tumor necrosis factor alpha factor,Lipopolysaccharide-induced tumor necrosis factor-alpha factor,LITAF,LITAF,LPS induced TNF alpha factor ,LPS-induced TNF-alpha factor,MGC116698,MGC116700,MGC116701,MGC125274,MGC125275,MGC125276,p53 induced gene 7 protein,p53-induced gene 7 protein,PIG 7,PIG7,SIMPLE,Small integral membrane protein of lysosome/late endosome,TP53I7,Tumor protein p53 inducible protein 7
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：Recombinant protein of human LITAF
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000 IHC1：50 - 1：200
Gene_ID（human）：9516
Swissprot：Q99732
Isotype：IgG
Research Areas：Epigenetics and Nuclear Signaling, Signal transduction
