Background：This gene encodes a member of the secreted leucine-rich repeat （LRR） superfamily and shares homology with members of the SLIT protein family. The encoded protein may regulate the activity of voltage-gated potassium channels and may be involved in neuronal growth regulation and cell survival. This gene is rearranged as a result of translocations in glioblastoma cell lines, and it is frequently down-regulated or rearranged in malignant gliomas. Mutations in this gene result in autosomal dominant lateral temporal epilepsy. Alternative splicing results in multiple transcript variants.
仕様
Synonyms：ADLTE,ADPAEF,ADPEAF,Epitempin 1,EPITEMPIN,Epitempin-1,EPT,ETL1,IB1099,leucine rich glioma inactivated 1,Leucine rich glioma-inactivated protein 1,Leucine-rich glioma-inactivated protein 1,LGI1,LGI1,OTTHUMP00000020121,OTTHUMP00000020122
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human LGI1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000
Gene_ID（human）：9211
Swissprot：O95970
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling, Neuroscience
