Background：This gene encodes a family member of actin-related proteins （ARPs）, which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF （BRG1/brm-associated factor） complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described.
仕様
Synonyms：53 kDa BRG1 associated factor A,Actin like 6A,Actin like protein 6A,Actin related protein,Actin related protein Baf53a,actin-related protein 4,ACTL 6,ACTL 6A,ACTL6,ACTL6A,Arp4,ARPN BETA,ArpNbeta,BAF 53,BAF 53A,BAF complex 53 kDa subunit,BAF53,BRG1 associated factor 53A,BRG1 associated factor,BRG1/brm associated factor 53A,hArpN beta,INO80 complex subunit K,INO80K,MGC5382
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human ACTL6A
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000
Gene_ID（human）：86
Swissprot：O96019
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling, Signal transduction
