Background：The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor （BAI1）-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
仕様
Synonyms：BAI-associated protein 2,BAI1 associated protein 2,BAI1-associated protein 2,BAIAP 2,Baiap2,BAIP2,BAP2,Brain-specific angiogenesis inhibitor 1-associated protein 2,Fas ligand-associated factor 3,FLAF3,Insulin receptor substrate p53,Insulin receptor substrate p53/p58,Insulin receptor substrate protein of 53 kDa,IRS-58,IRSp53,IRSp53/58,Protein BAP2
Host：Rabbit
Reactivity：Human,Rat
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：Recombinant protein of human BAIAP2
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
