Background：This gene encodes a PDZ domain-containing scaffolding protein. PDZ domain-containing molecules bind to and mediate the subcellular localization of target proteins. The encoded protein mediates the localization of cell surface proteins and plays a critical role in cholesterol metabolism by regulating the HDL receptor, scavenger receptor class B type 1. Single nucleotide polymorphisms in this gene may be associated with metabolic syndrome, and overexpression of this gene may play a role in drug resistance of multiple myeloma. Pseudogenes of this gene are located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
仕様
Synonyms：1700023D20Rik,2610507N21Rik,4921513F16Rik,AI267131,AI314638,AL022680,C terminal linking and modulating protein,CAP70,CFTR associated protein of 70 kDa ,CFTR associated protein, 70-KD,CFTR-associated protein of 70 kDa,CLAMP,D3Ertd537e,Dietary Pi-regulated RNA-1,Diphor-1,mPDZK1,Na（+）/H（+） exchange regulatory cofactor NHE-RF3,Na（+）/H（+） exchanger regulatory factor 3,Na/Pi cotransporter C-terminal-associated protein 1,Na/Pi cotransporter C-terminal-associated protein,NaPi Cap1,NaPi-Cap1,NaPiCap1,NHERF 3,NHERF-3,NHERF3,NHRF3,OTTHUMP00000015572 ,PDZ domain containing 1,PDZ domain containing protein 1,PDZ domain-containing protein 1,PDZD1,PDZK1,Sodium hydrogen exchanger regulatory factor 3,Sodium-hydrogen exchanger regulatory factor 3
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human PDZK1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB 1：500 - 1：2000
Gene_ID（human）：5174
Swissprot：Q5T2W1
Isotype：IgG
Research Areas：Cancer, Metabolism, Signal transduction
