Background：This gene encodes a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. The encoded preproprotein present in plasma as a non-covalent complex with high molecular weight kininogen undergoes proteolytic processing mediated by activated coagulation factor XII to generate a disulfide-linked, heterodimeric serine protease comprised of heavy and light chains. Certain mutations in this gene cause prekallikrein deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms.
仕様
Synonyms：Fletcher factor,kallikrein B plasma,Kallikrein B plasma （Fletcher factor） 1,Kallikrein B,plasma 1,Kallikrein B1,Kininogenin,KLK3,KLKB1,KLKB1,PKK,PKKD,Plasma kallikrein,Plasma kallikrein B1,Plasma kallikrein light chain,Plasma prekallikrein,PPK,Prekallikrein
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：Recombinant protein of human KLKB1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000 IHC1：50 - 1：200
Gene_ID（human）：3818
Swissprot：P03952
Isotype：IgG
Research Areas：Cancer, Cell Biology, Cardiovascular, Signal transduction
