Background：The protein encoded by this gene is a member of the Toll-like receptor （TLR） family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide （LPS） found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene.
仕様
Synonyms：ARMD10,CD284,CD284 antigen,Homolog of Drosophila toll,hToll,TLR 4,TLR4,TLR4,TOLL,Toll like receptor 4,Toll-like receptor 4
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：A synthetic peptide of human TLR4
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000 IHC1：100 - 1：200
Gene_ID（human）：7099
Swissprot：O00206
Isotype：IgG
Research Areas：Cancer, Cardiovascular, Immunology, Microbiology
