Background： Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.
仕様
Synonyms：Frizzled 7,seven transmembrane spanning receptor,frizzled class receptor 7,Frizzled drosophila homolog of 7,Frizzled family receptor 7,Frizzled homolog 7,Frizzled-7,Frizzled7,Fz 7,Fz-7,Fz7,FZD 7,FZD7,FZD7,FzE 3,FzE3,hFz 7,hFz7,Homolog of Drosophila Frizzled 7,OTTHUMP00000163742
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human FZD7
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000
Gene_ID（human）：8324
Swissprot：O75084
Isotype：IgG
Research Areas：Cancer, Signal transduction, Stem cells
