Background：The protein encoded by this gene is a cyclin-dependent kinase 2 （CDK2） -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation （NURD） complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
仕様
Synonyms：CDK2 A1,CDK2 associated protein 1,CDK2-associated protein 1,CDK2AP1,CDKA1,CDKA1,Cyclin dependent kinase 2 associated protein 1,Cyclin-dependent kinase 2-associated protein 1,Deleted in oral cancer 1,DOC 1,DOC 1 related protein,DOC 1R,DOC-1,DOC1,DOC1R,DORC1,p12DOC 1,Putative oral cancer suppressor,ST19
Host：Rabbit
Reactivity：Human
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human CDK2AP1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
