Background：This gene encodes a member of the AAA （ATPases associated with diverse cellular activities） superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. Two encoded proteins, described as major and minor isoforms, have been localized to distinct regions of the nucleus. The largest encoded protein （major isoform） has been localized to the nucleolus and shown to participate in ribosome biosynthesis （PMID： 15469983, 16782053）, while the minor isoform has been localized to the nucleoplasmin.
