Background：This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved （CAP-GLY） domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
