Background：This gene encodes a member of the aldehyde dehydrogenase protein family. The encoded protein is a mitochondrial methylmalonate semialdehyde dehydrogenase that plays a role in the valine and pyrimidine catabolic pathways. This protein catalyzes the irreversible oxidative decarboxylation of malonate and methylmalonate semialdehydes to acetyl- and propionyl-CoA. Methylmalonate semialdehyde dehydrogenase deficiency is characterized by elevated beta-alanine, 3-hydroxypropionic acid, and both isomers of 3-amino and 3-hydroxyisobutyric acids in urine organic acids. Alternate splicing results in multiple transcript variants.
仕様
Synonyms：1110038I05Rik,AI314632,Aldehyde dehydrogenase 6 family member A1,Aldehyde dehydrogenase family 6 member A1,Aldehyde dehydrogenase family 6,subfamily A1,ALDH6A1,Malonate semialdehyde dehydrogenase,Malonate-semialdehyde dehydrogenase [acylating],Methylmalonate semialdehyde dehydrogenase [acylating] mitochondrial,Methylmalonate-semialdehyde dehydrogenase [acylating],MGC37325,MGC40271,Mitochondrial acylating methylmalonate semialdehyde dehydrogenase,mitochondrial,MMSA,MMSADHA,MMSDH
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human ALDH6A1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000
Gene_ID（human）：4329
Swissprot：Q02252
Isotype：IgG
Research Areas：Cancer, Metabolism, Signal transduction
