Background：Huntington's disease （HD）, a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II.
仕様
Synonyms：EC 2.1.1.43,FLJ16420,FLJ22472,FLJ23184,FLJ45883,HBP231,HIF 1,HIF-1,HIF1,HIP-1,Histone lysine N methyltransferase SETD2,Histone-lysine N-methyltransferase SETD2,hSET2,HSPC069,Huntingtin interacting protein 1,Huntingtin interacting protein,Huntingtin interacting protein B,Huntingtin interacting protein HYPB,Huntingtin yeast partner B,Huntingtin-binding protein,231-KD,Huntingtin-interacting protein 1,Huntingtin-interacting protein B,HYPB,KIAA1732,KMT3A,Lysine N methyltransferase 3A,Lysine N-methyltransferase 3A,p231HBP,SET domain containing 2,SET domain-containing protein 2,SET2,SETD2,SETD2
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human SETD2
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Dilution：WB1：500 - 1：2000
Gene_ID（human）：29072
Swissprot：Q9BYW2
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
