Background：The protein encoded by this gene is a member of the 7 transmembrane-spanning G protein-coupled receptor family, and functions as a receptor for the endogenous, opioid-related neuropeptide, nociceptin/orphanin FQ. This receptor-ligand system modulates a variety of biological functions and neurobehavior, including stress responses and anxiety behavior, learning and memory, locomotor activity, and inflammatory and immune responses. A promoter region between this gene and the 5'-adjacent RGS19 （regulator of G-protein signaling 19） gene on the opposite strand functions bi-directionally as a core-promoter for both genes, suggesting co-operative transcriptional regulation of these two functionally related genes. Alternatively spliced transcript variants have been described for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon.
仕様
Synonyms：H.sapiens mRNA for ORL1 receptor,Kappa type 3 opioid receptor,Kappa-type 3 opioid receptor,kappa3-related opioid receptor,KOR 3,KOR-3,KOR3,LC132 receptor like,LC132 receptor,rat,homolog of,MGC34578,Nociceptin receptor,Nociceptin/orphanin FQ （N/OFQ） peptide receptor,NOCIR,NOP,OOR,Opiate receptor like 1,Opiod receptor like 1,Oprl1,OPRX,ORL1,Orphanin FQ receptor
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB
Concentration：1mg/ml
Immunogen：A synthetic peptide of human OPRL1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000
Gene_ID（human）：4987
Swissprot：P41146
Isotype：IgG
Research Areas：Cancer, Metabolism, Neuroscience, Signal transduction
