Background：This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B （NFkB）. The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants.
仕様
Synonyms：CVID10,DNA binding factor KBF2,H2TF1,Lymphocyte translocation chromosome 10 protein,LYT 10,NF kB2,NFKB p52/p100 subunit,Nuclear factor Kappa B subunit 2,Nuclear factor of kappa light polypeptide gene enhancer in B cells 2 （p49/p100）,Nuclear factor of kappa light polypeptide gene enhancer in B cells 2,Oncogene Lyt 10,p100,Transcription factor NFKB2
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：A synthetic peptide of human NFKB2
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000 IHC1：50 - 1：200
Gene_ID（human）：4791
Swissprot：Q00653
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling, Signal transduction
